Thursday, February 08, 2007

TELK: License Agreement for C243 in MS, Autoimmune and Inflammatory Diseases

Market News Publishing US - Feb. 08, 2007


By Fain Hughes,

SRI International, an independent nonprofit research and development organization, and Telik, Inc. (TELK) announced that they have signed an exclusive license agreement under which SRI will conduct preclinical studies of a Telik drug candidate for the treatment of multiple sclerosis and other autoimmune and inflammatory diseases.

The licensing agreement involves the study of C243, a compound that prevents leukocyte infiltration. Leukocytes are white blood cells that help defend the body against infection. Leukocyte infiltration is strongly linked to tissue injury in chronic autoimmune and inflammatory diseases such as multiple sclerosis, rheumatoid arthritis, and atherosclerosis.

Under the terms of the agreement, SRI will fund and conduct preclinical and toxicology studies directed at supporting an Investigational New Drug (IND) application filing for C243 with the FDA, as well as develop GMP-compliant sources for C243 manufacturing. Telik will have the option to re-acquire C243 rights in the future. In North and South America, Telik has exclusive commercialization rights to C243. Sanwa Kagaku Kenkyusho, Co., Ltd. and Telik share commercialization rights to the compound in Europe, and Sanwa has exclusive commercialization rights in Asia. The license agreement covers territories where Telik has exclusive rights.

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